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In another analyze, intracerebroventricular injection of modafinil enhanced histamine launch in anesthetized rats Whilst direct injection in to the tuberomammillary nucleus did not, suggesting histaminergic neurons ended up in a roundabout way qualified (Ishizuka et al 2003). Others have demonstrated modafinil may perhaps potentiate the snooze-inhi
In vivo studies show anatomically selective neurochemical effects of modafinil on monoaminergic systems (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, when modafinil will increase TMN fos expression (Scammell et al 2000) and HAergic tone it is unable to exert this result when administered straight into the TMN (Ishizuka et al 2003